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Biotech / Medical : Sorrento Therapeutics Inc

SRNE 0.00180

0.0%

Dec 22 9:30 AM EST

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From: Julius Wong	12/6/2021 7:14:47 AM
	of 171

Sorrento reports publication of a series of SARS-CoV-2 MPro inhibitors for treatment of COVID-19 Dec. 06, 2021 5:00 AM ET Sorrento Therapeutics, Inc. (SRNE) By: Mamta Mayani, SA News Editor peterschreiber.media/iStock via Getty Images Sorrento Therapeutics (NASDAQ: SRNE) announces the peer-reviewed publication of a series of novel SARS-CoV-2 MPro inhibitors with potent activities for both MPro and cathepsin L, a key host enzyme for SARS-CoV-2 entry into host cells at Texas A&M University. Shares up 7.4% premarket at $5.31. SARS-CoV-2 main protease (MPro) is a key enzyme for the viral life cycle including virus entry, replication and packaging. In the publication, a representative analog of the series, MPI8, demonstrated dual inhibition of MPro and cathepsin L with high potency and selectivity (IC50 values for MPro and cathepsin L are 105 nM and 1.2 nM, respectively). A promising analog with features distinguished from current reported SARS-CoV-2 MPro inhibitors has been systematically evaluated and advanced to a late stage of pre-clinical phase. "The oral MPro inhibitor together with Sorrento’s other ongoing therapeutic intervention approaches reflect our efforts to create a ‘mutation-agnostic’ global anti-COVID strategy to combat COVID-19 variants of concern, including the emerging Omicron variant,” stated Dr. Henry Ji, Chairman and CEO of Sorrento.

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