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Strategies & Market Trends : 2026 TeoTwawKi ... 2032 Darkest Interregnum
GLD 383.12+0.8%Nov 26 4:00 PM EST
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marcher
To: Roads End who wrote (181511)12/16/2021 7:41:14 AM
From: Pogeu Mahone1 Recommendation   of 218056
 
One stoss dose

one day cure.

Or the eye of a newt for a week of suffering.

1. If an otherwise healthy adult tried to kill himself by taking an entire bottle (250 capsules) of 1,000 iu cholecalciferol, which of the following would happen?

a) The person would die within 24 hours from severe hypercalcemia and widespread calcinosis.
b) If the person received intensive treatment for hypercalcemia he may survive.
c) Hypercalcemia would be severe but require only supportive treatment.
d) Such doses are called "Stoss" therapy and are occasionally used therapeutically although they do not replicate normal physiology. As most Americans are vitamin D deficient, such a one-time dose would probably be a health benefit for the majority of Americans.

The correct answer is d. One of the most recent examples is the use of stoss therapy to reduce fracture rates in the elderly (100,000 IU of oral cholecalciferol every four months for five years) by Dr. Trivedi and colleagues (University of Cambridge School of Clinical Medicine) published in the British Medical Journal. How high do you think average 25-hydroxyvitamin D levels were in the subjects after they received 100,000 IU of cholecalciferol every four months for five years? Answer: about 29 ng/ml, still mildly deficient! ( Source)
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