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Biotech / Medical : Agouron Pharmaceuticals (AGPH)
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To: Henry Niman who wrote (3766)2/7/1998 5:09:00 PM
From: David S.  Read Replies (1) of 6136
 
Reply-To:
Crixivan E-Mail Discussion List <Crix-List@PinkPage.com>
To:
crix-list@pinkpage.com

On Fri, 6 Feb 1998 17:35:52 -0500, you wrote:

>Various postings have asked whether it is safe to switch from IND to NFV if
>viral load is <500 to either avoid side effects or for an easier regime.
>
>An abstract (387) at last weeks Chicogo Conference had looked at switching
>protease inhibitors when viral load was undetectable (<500).
>
>Of the 39 people studied, 13 were originally on an indinavir combination
>and 26 were on a combination including ritonavir & saquinavir.
>
>The follow-up viral load test 6 weeks after the change showed 26per cent of
>people had developed viral load levels above 500. This is a very high rate
>especially as all patients had previoulsy been undetectable for at least 6
>months.

True; these observational data do sound a note of caution about this
switch.

As a caveat, though, we don't know whether many of these individuals
might have had viral load rebounds even if they had stayed on their
original regimen. Only a randomised study of switching could answer
this question definitively.

But in the absence of such a study, it might indeed be safest to
assume 'if it ain't broke, don't fix it'...

Edward King
AIDS Guide at The Mining Company
aids.miningco.com
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