SI
SI
discoversearch

We've detected that you're using an ad content blocking browser plug-in or feature. Ads provide a critical source of revenue to the continued operation of Silicon Investor.  We ask that you disable ad blocking while on Silicon Investor in the best interests of our community.  If you are not using an ad blocker but are still receiving this message, make sure your browser's tracking protection is set to the 'standard' level.
Politics : The Trump Presidency
 Public ReplyPrvt ReplyMark as Last ReadFilePrevious 10Next 10PreviousNext  
Recommended by:
i-node
To: J_F_Shepard who wrote (225105)2/7/2022 10:19:09 AM
From: Thomas M.1 Recommendation  Read Replies (2) of 361484
 
Ivermectin Mechanism #1

Ivermectin blocks the virus from entering cells.
ivermectin docked in the region of leucine 91 of the SARS-CoV-2 spike protein and histidine 378 of the host cell ACE-2 receptor blocking its entry into the host cell

pubmed.ncbi.nlm.nih.gov

Ivermectin showed 5 important docking properties:

  • Highest binding affinity to the predicted active site of the S glycoprotein (Moldock score -140.584) and protein–ligand interactions (Moldock score -139.371).

  • Considerable binding affinity to the predicted active site of the SARS-CoV-2 RdRp protein (Moldock score -149.9900) and protein–ligand interactions (Moldock score -147.608), it formed H-bonds with only two amino acids: Cys622 and Asp760.

  • Highest binding affinity (Moldock score -212.265) to the predicted active site of nsp14.

  • The highest binding affinity to the active site of the TMPRSS2 protein (Moldock score -174.971) and protein–ligand interactions (Moldock score -180.548). Moreover, it formed five H-bonds with Cys297, Glu299, Gln438, Gly462, and Gly464 amino acid residues present at the predicted active site of the TMPRSS protein.

  • The free binding energy of the spike protein (open) was higher in ivermectin (-398.536?kJ/mol) than remdesivir (-232.973?kJ/mol).


    • frontiersin.org

    Tom
    Report TOU ViolationShare This Post
     Public ReplyPrvt ReplyMark as Last ReadFilePrevious 10Next 10PreviousNext  

    HomeMailHotSubjectMarksPeopleMarksKeepersSettings
    Terms Of UseContact UsCopyright/IP PolicyPrivacy PolicyAbout UsFAQAdvertise on SI
    © 2026 Knight Sac Media.  Data provided by Twelve Data, Alpha Vantage, and CityFALCON News