Ivermectin has shown antiviral effects on RNA viruses such as Zika, dengue, yellow fever, West Nile, Hendra, Newcastle, Venezuelan equine encephalitis, chikungunya, Semliki Forest, Sindbis, Avian influenza A, Porcine Reproductive and Respiratory Syndrome, Human immunodeficiency virus type 1, and severe acute respiratory syndrome coronavirus 2.

nature.com

The integrase (IN) molecule of human immunodeficiency virus (HIV)–1 is of particular interest in this context due to its integral role in integrating the HIV genome into that of the infected host cell. Most IN-based antiviral compounds target the IN/DNA interaction, but since IN must first enter the nucleus before it can perform these critical functions, nuclear transport of IN is also an attractive target for therapeutic intervention.

This study has identified ivermectin as a potential general IMP a/ß-mediated nuclear import inhibitor, which does not appear to affect nuclear import mediated by IMP ß1 alone. Although ivermectin is a broad-spectrum antiparasitic agent, which functions by modulating a7 sodium channels, the results here suggest it may also prove useful in future studies examining IMP a/ß–mediated nuclear import.

journals.sagepub.com

Treatment of cells with Ivermectin, an anti-parasitic drug which has been recently identified as an inhibitor of importin a/ß-dependent nuclear transport, reduced UL42 nuclear import and specifically reduced BoHV-1 replication

mdpi.com