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Politics : The Trump Presidency
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To: J_F_Shepard who wrote (225105)2/7/2022 9:01:53 PM
From: Thomas M.  Read Replies (1) of 361488
 
Ivermectin Mechanism #11

PAK1 binds to STAT-3 and the resultant complex activates IL-6 which is responsible for cytokine storm:
The PAK1-Stat3 Signaling Pathway Activates IL-6 Gene Transcription

PAK1 interacts with signal transducer and activator of transcription 3 (Stat3), and PAK1 and Stat3 colocalize in the nucleus.

the PAK1/Stat3 complex binds to the IL-6 promoter and regulates the transcription of the IL-6 gene. Inhibition of PAK1 and JAK2 in mammospheres reduces the nuclear pStat3 and extracellular IL-6 levels.

mdpi.com
Ivermectin inhibits PAK1:
Our data showed that ivermectin could markedly decrease the expression of PAK1

Ivermectin downregulated PAK1 protein levels by targeting the lysine residues at K11, K29, K39, or K148 and promoting ubiquitination-mediated degradation. These results support ivermectin as a potent agent in the induction of ubiquitination-mediated degradation of PAK1

cancerres.aacrjournals.org
Tom
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