Vivus: into single digits Message Board

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Biotech / Medical : Vivus: into single digits

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To: MIKE DUBIS who wrote (62)	2/9/1998 8:51:00 PM
From: BigKNY3	Read Replies (3) of 1016

Mike: Here are some comments concerning posts placed by a famous VVUS investor. I believe he may be a physician from his earlier posts and not a MBA. I don't know if he has any sisters. <<The retina also has PDE V>> <<PDE selectivity is very narrow>> Note: the lack of references here. In the definitive research book on PDEs "Phosphodiesterase Inhibitors" by Christian Schudt et al, Academic Press, there is not a single reference that PDE-V is found in the retina. The book states: - "two types of PDEV which hydrolyse cGMP are present in smooth muscle." -"The type VI PDEs are found in the photoreceptors and are involved in visual signalling pathways". Moreover, the authors conclude: "In view of the different functions and the tissue localization of isoenzyme subtypes, synthesis of subtype-selective PDE inhibitors has already started and provides a challenge to chemists, biochemists and pharmacologists. Again, such compounds may bear an enormous potential for research in physiology and pathology on the one hand, and on the other for the therapy of a broad range of diseases." In the many Viagra posts placed by this VVUS supporter, he lists references to non-specific PDEs, PDE-IIIs and PDE-VIs inhibitors....never PDE-Vs. Note in his reference to a Science article he does not state that the entire article is referring to the gamma and alpha and beta subunits of PDE-VI. www3.techstocks.com. I can only assume that this VVUS investor has concluded that Viagra is a non-specific PDE inhibitor at high doses (again no basis for this theory) or he is spreading misinformation in a effort to protect his growing VVUS portfolio. Either way, potential and current VVUS investors should be aware of the facts and should not be misled by misinformation. BigKNY3

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