Zebra,thanx, for the short info.Here is from the "other Vivus" thread:
Message 3397794
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To: +BigKNY3 (64 )
From: +Tunica Albuginea Tuesday, Feb 10 1998 11:55PM EST
Reply # of 69
BigKNY3, here is the reference you requested. It is more authoritative than your source.The reason why doctors have a hard time evaluating the true efficacy of drugs is because of the blue smoke and mirrors emanating from the PR Depts of most Drug Cos and the uninformed support they get from lay people, including those with MBAs or PhDs but not MD degrees.This is why also we have the other big scam: the health food industry, but that is another issue.This data was previously posted by me and this posting would not have been
necessary if you had taken the time to read them ( or at least the original textbook ).Somewhere along the line you need to explain the " blue halo " effect of Viagra on patients ( you haven't so far ).
PS Don't spend too much time trying to convince DrDale Russell in your lonesome corner of all this mumbojumbo on PDE selectivity. DrRussell knows better than that. Maybe you should read his preface to this thread.
TA
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From
GOODMAN & GILLMAN'S
THE PHARMACOLOGICAL
BASIS OF
THERAPEUTICS
NINTH EDITION, 1997
( The no 1 , US Medical School, Textbook of Pharmacology )
I abstracted in quotation, verbatim, the specific answer to your questions;
I capitalized important points.
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Chapter 34 Page 833 .
" MANY organs, including cardiac muscle, contain members OF ALL KNOWN PDE isoenzyme families (Bode et al., 1991: Nicholson et al., 1991)."
"The SPECIFICITY of the "selective" inhibitors noted in Table 34-8 is RESTRICTED for most PDE isoenzymes to a RELATIVELY NARROW concentration range, with NON-SPECIFIC INHIBITION evident at HIGHER concentrations. "
(tab;e 34-8 is from Nickolson 1991, summarized as follows: PDE-I: CNS modulation
PDE-III: Positive inotropism
PDE- IV: Airway smooth muscle relaxation
PDE- V: Penile erection
PDE-VI: Photoreceptor
PDE-VII: Skeletal muscle
"In addition, MOST of these inhibitors have OTHER known pharmacoloaical activities '
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The original posts for the above::
- phosphodiesterase ( PDE ) sideffects
- PDE ):Taken from Goodman & Gillman 1996 ED.Textbook of
pharmacology.
www3.techstocks.com
- www3.techstocks.com
TA |
