BigKNY3, in answer to your questions:
" Question #1 for TA: Does the Table 34-8 in Goodman and Gilman list include Viagra (sildenafil)? Yes or no? ".
A: The answer is no because Sildenafil is too new and unknown.
Table 34-8 instead lists all the other PDE inhibitors, ALL MAJOR
CARDIOVASCULAR POISONS AND KILLERS.
In case you forgot:
www3.techstocks.com
Sildenafil will be tested in ? phase IV into millions of hapless
Americans , just like Redux, who will be the real guinea pigs.
Approximately 3-4 yeas from now, when all the nasties are known ,
then at that time Good & Gill will list Sildenafil with it's
major sideffects. In the same fashion that 3 days ago Hismanal was
added Seldane as a cause of malignant deadly arrhythmia's, ( and
that's in normal people!!).Wait until the polypharmacy drug
elderly ED patients start taking Sildenafil. It will be a
cardiologist 's next nightmare IMHO.
"Question #2 for TA :Does the May,17, 1996 Science article on retinal degeneration refer specifically to PDE-VI in mice (not PDE-Vs which you have incorrectly stated in your posts). Yes or no? ".
A: It does not list any PDE by name. Just the subunits that THEY DISCOVERED. In other words other PDEs are in the retina as Good&Gill told you. We have only discovered a tiny fraction.Same as the prostaglandins. It took 5 years of Non_Steroidals to be in the market before we found out how adversely they affected prostaglandins, renal function, renal failure in certain conditions.Again from Good&Gill "PDEsare WIDELY distributed with many different PDEs in one organ.
What you don't seem to understand is that Nicholson's classification of 6 different PDEs is NOT the Bible! It is an old, temporary classification, of the LIMITED knowledge.Don't hang your hat on it.
What you need to do is get hold of a nice recent ophthalmology textbook and read up on the No 1 cause of blindness in the USA: Macular Degeneration; And read how in it Cyclic GMP is increased. That is exactly the chemical that Sildenafil will increase in the penis to give you an erevtion.Except that when it happens in the retina it is assosciated with retinal destruction
Finally Big K , I want you to quote me a single doctor ( MD ) on this thread, the Vivus 1997/1998 thread, the PFE thread, in SI , Yahoo, or ANYWHERE that feels strongly about Viagra replacing Vivus.
I instead can quote you several doctors who are for Vivus. It would take too much of my time now for me to explain why no docs are FOR Viagra ( I am saying supportive off, NOT INTERESTED in- big difference ) on these threads.
Good luck with PFE at PE 43? GG.No major recent discovery:
- the much touted Lipitor WAS DISCOVERED by Warner Lambert. PFE just
sells it.
-Broad spectrum Trovan is exactly the sort of bad drug any infectious disease specialist will tell you has recently flooded the market: Broad specrum drugs are what kills everything, encourages overgrowth of resistant organisms to all antibiotics and may soon result in massive deaths from resistant organisms.
Sorry Big K . I know you try hard but it just ain't enough.
TA
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