Scientists Discover That Hibiscus Tea Could Defeat Alzheimer’s Disease and maintain a cleaner brain with better memory - Gossypetin ameliorates 5xFAD spatial learning and memory through enhanced phagocytosis against Beta-Amyloid (Aß) lnkd.in - see lnkd.in
There are many reasons to enjoy a cup of ruby red hibiscus tea, including its ability to warm the body in the winter, boost the immune system, regulate blood pressure, and aid in weight loss.
Microglia are the resident immune cells found in our brains. They have a critical role in brain maintenance. Microglia constantly scavenge various waste materials in the brain including damaged or apoptotic neurons and Aß. Through phagocytosis of Aß, microglia prevent the accumulation of Aß plaque in the brain. However, in Alzheimer’s disease (AD) patients, chronic exposure to Aß makes microglia exhausted, reducing their phagocytic activity against Aß. Since microglia play an important role in Aß clearance, enhancing microglial phagocytic activity against Aß is a promising target for AD treatment. Therefore, there is a great need for a therapeutic candidate that enhances microglial Aß clearance while inhibiting microglia’s pathogenic properties.
Now, research has found that it could defeat Alzheimer’s disease.
Professor Kyong-Tai Kim and Ph.D. candidate Kyung Won Jo, from the Department of Life Sciences at POSTECH, have found that the gossypetin in the hibiscus activates microglia, the immune cells in the brain. Their research also showed that these microglia could scavenge amyloid-beta in the brain to improve cognitive function in individuals with Alzheimer’s.
Gossypetin treatment improved the spatial learning & memory of 5xFAD by decreasing Aß deposition in the hippocampus & cortex of 5xFAD. Gossypetin-induced transcriptomic modulations in various microglial subpopulations, including disease-associated microglia. Gossypetin enhanced the phagocytic activity of microglia while decreasing their gliosis.
Gossypetin showed protective effects against AD by enhancing microglial Aß phagocytosis. Gossypetin appears to be a novel promising therapeutic candidate against AD.
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