Didn't want you to miss this paper CW
ncbi.nlm.nih.gov
Science 1998 Feb 6;279(5352):863-867
Impaired Locomotion and Dopamine Signaling in Retinoid Receptor
Mutant Mice.
Kr&ecedil;zel W, Ghyselinck N, Samad TA, Dup‚ V, Kastner P, Borrelli E, Chambon P
Institut de G‚n‚tique et de Biologie Mol‚culaire et Cellulaire, CNRS, INSERM, Universit‚
Louis Pasteur, CollŠge de France, Boite Postale 163, 67404 Illkirch Cedex, France.
[Record supplied by publisher]
In the adult mouse, single and compound null mutations in the genes for retinoic acid receptor beta and retinoid X receptors beta and gamma resulted in locomotor defects related to dysfunction of the mesolimbic dopamine signaling pathway. Expression of the D1 and D2 receptors for dopamine was reduced in the ventral striatum of mutant mice, and the response of double null mutant mice to cocaine, which affects dopamine signaling in the mesolimbic system, was blunted. Thus, retinoid receptors are involved in the regulation of brain functions, and retinoic acid signaling defects may contribute to pathologies such as Parkinson's disease and schizophrenia.
PMID: 9452386 |
