Ligand (LGND) Breakout! Message Board

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Biotech / Medical : Ligand (LGND) Breakout!

LGND 202.02

+0.4%

3:28 PM EST

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To: Henry Niman who wrote (15042)	2/13/1998 10:23:00 PM
From: Vector1	Read Replies (2) of 32384

Henry, could you please explain <<Unlike like xenografts (human clones put into nude, immunodefective, mice, the NMU tumors were heterogeneous and arose over time>> Isn't Xenograft the standard approach. How were the mice developed. There was an interesting article we talked about a while back in the special issue of Science. The discussion centered around the isssue that many promising cancer drugs in Xenografted tumors in Mice do not perform in humans. The primary reason is two fold. Toxicity and the fact that Xenografted tumors are not metastatic. I have not read the article but it appears that niether of these are issues in the Ligand preclinicals for Breast Cancer as Targretin has shown to be safe in hundreds of patients and the rat model used have metastatic a tumors. V1

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