Ligand (LGND) Breakout! Message Board

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Biotech / Medical : Ligand (LGND) Breakout!

LGND 200.79

-0.2%

Nov 14 9:30 AM EST

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To: Vector1 who wrote (15044)	2/13/1998 11:23:00 PM
From: squetch	Read Replies (1) of 32384

>>The discussion centered around the isssue that many promising cancer drugs in Xenografted tumors in Mice do not perform in humans. The primary reason is two fold.<< V1, This paper mention a third issue. Xenografted tumors also lacked the cellular architecture of the natural tumor environment. So in xenograft tumors you can only look at effect on tumor. This has implications if the therapy were to interact w/ the surrounding environment. The paper also says the NMU model has been used extensively to analyze the effects of antiestrogens, such as Tamox. and raloxifen, on prevention of mammary carcinogenesis and therapy of established breast tumors. Definitely secondary tumor growths.

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