Ligand (LGND) Breakout! Message Board

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Biotech / Medical : Ligand (LGND) Breakout!

LGND 192.84

-1.7%

3:59 PM EST

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To: Flagrante Delictu who wrote (15052)	2/14/1998 4:26:00 AM
From: Henry Niman	Read Replies (1) of 32384

Bernie, I have posted the abstract. The retinoids were those specific for RARs such as tretinoin and isotretinoin (active ingredients in Retin-A, Renova, Accutane, and Vessinoid). The article itself is fairly long and I just have a hard copy. I'll post more details later. However, for breast cancer (at least in this animal model), the major activity seemed to reside in the ligands that reacted with RXRs (Rexinoids), not RARs (Retinoids). The model has been used to show activity by Tamoxifen as well as Raloxifene (LLY's Evista), both of which are anti-estrogens.

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