Ligand (LGND) Breakout! Message Board

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Biotech / Medical : Ligand (LGND) Breakout!

LGND 203.62

+1.2%

1:43 PM EST

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To: Vector1 who wrote (15044)	2/14/1998 4:42:00 AM
From: Henry Niman	Read Replies (2) of 32384

V1, I'll give more details later, but the PNU rat model treats (IV injection) the mice with a carcinogen, PNU, which causes them to develop breast cancer. The tumors are adenocarcinoma, like the most frequent type of human breast cancer, and is a much more "natural" process. Targretin previously has been shown to PREVENT these tumors from developing (as has Tamoxifen), but in this study they allowed the tumors to develop, and then treated the rats. The results were stunning (the breast tumors disappeared in 72% of the rats). Thus, in this model, the drug is used to treat a rat tumor that develops from exposure to a carcinogen. In xenografts, a human tumor is placed in immunocompromised animals (usually nude mice) and then treated (a fairly artificial situation).

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