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Biotech / Medical : Ligand (LGND) Breakout!
LGND 200.79-0.2%Nov 14 9:30 AM EST
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To: Andrew H who wrote (15135)2/15/1998 4:10:00 PM
From: Henry Niman  Read Replies (1) of 32384
 
Andy, I was referring to energy metabolism. AIDS patients on PIs not only have their fat rearranged, but they also run into problems with diabetes. Energy metabolism and insulin resistance are controlled by the same general classes of receptors. The critical heteropulex for insulin resistance is PPAR gamma paired up with RXR alpha (which is activated by Targretin). For energy metabolism, its PPAR alpha, also paired up with an RXR (it may also be alpha, but the subtype is irrelevant because Targretin activates all three RXR subtypes).
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