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Pastimes : Heart Attacks, Cancer and strokes. Preventative approaches
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To: carranza2 who wrote (38550)12/21/2023 11:24:49 AM
From: carranza21 Recommendation

Recommended By
pheilman_

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More to the increasingly-known paradox that statins promote arterial calcification while reducing mortality due to heart disease. From a recent study (p. 11):

mdpi-res.com 1702373236

This paradoxical effect of statin is not completely understood. Statins are postulated to alter the progression and microarchitecture of the calcium deposits by altering their size distribution and density. This change may lead to the coalescence of these calcium deposits, a reduced mineral surface area, and potentially contributing to enhanced plaque stability and ultimately diminishing the risk of plaque rupture [120,121].

The article is cutting edge, but somewhat troublesome to read thanks to the dense scientific language. The bottom line, as I see it, is that genetics and the gut biome will play a more significant role in future advances. Statins are OK even though they likely promote calcification but in a more or less harmless for most of us.

If you are lucky enough to have low ApoB and lp(a) scores, calcification may not be as big of a problem. The study does not mention them. It barely mentions vitamin K2.

The issue is seriously complex. It has taken decades of statin use for the latest findings to be made and interpreted. I wonder if the latest wonder drug, pcsk9 inhibitors, will follow suit.

The best drug, however, is a healthy lifestyle. Always has been.
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