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Biotech / Medical : Biotech Valuation
CRSP 61.65-3.7%9:30 AM EST
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To: software salesperson who wrote (52101)1/21/2024 9:45:48 AM
From: software salesperson2 Recommendations

Recommended By
Lance Bredvold
sjemmeri

   of 52153
 
additional reasons over and above fewer side effects that novavax is better than MRNA covid vaccines.

via michael lin, stanford.

1 ) 3x RNA vaccines induce IgG4 antibodies, which clear antigens poorly and is associated with immunotolerance. By contrast, 3x Novavax does not induce IgG4.

2) And here's a recent review on Novavax having fewer side effects "Evidence suggests that NVX-CoV2373, when utilized as a heterologous booster, demonstrates less reactogenicity compared with mRNA vaccines."

3) Here's the evidence the Novavax vaccine format may induce broader responses (more protective to future variants). Note was studied with the first Novavax vaccine (Wuhan D614G) against Omicron as the variant.

4) But RNA has cytotoxic T cell responses. So I had said that personally I will try getting them in alternate years to get the best of both.

5) Today's results provide another reason potentially to alternate. It also suggests Novavax would be better if we ever need 2 vaccines within a year. Given how fast variants are evolving, FDA should consider providing people that option.
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