| | | New long COVID discoveries:
New research offers possible cause for long COVID
March 11, 2024 at 8:04 pm
By
Lisa M. Krieger
Bay Area News Group
Pieces of the COVID virus can lurk in our blood and tissue for more than a year after the initial illness has vanished, a discovery that might offer clues to the mystery of lingering post-infection disability, according to new research from UC San Francisco.
Four years after the U.S. went into lockdown, the worst of the pandemic has passed. But for people with long COVID, the illness remains a daily misery.
The new research suggests why: The virus is not always fully cleared after the initial infection, so remains embedded, even though people are no longer contagious.
More on COVID-19 It is not yet known if these small viral proteins, called antigens, are causing long COVID. But, based on the new discovery, the UCSF team is conducting clinical trials of potential therapies that could attack the hidden pathogen.
“There is a lot more work to be done, but I feel like we are making progress in really understanding the long-term consequences of this infection,” said infectious disease expert Dr. Michael Peluso, who presented the research at last week’s Conference on Retroviruses and Opportunistic Infections.
While COVID remains much more serious than the usual seasonal flu, safe and highly effective vaccines have caused a dramatic decline in infections and deaths.
There is a desperate need for a diagnostic test and treatment for long COVID, which affects an estimated 7% of American adults. Currently, doctors are only treating the symptoms, rather than offering a cure. Experts predict that the disorder will place continuing demands on our health care system.
“Long COVID patients deserve swift, accurate diagnosis and timely, effective treatment,” said Jaime Seltzer, scientific director at the nonprofit MEAction, which advocates for patients with long COVID and myalgic encephalomyelitis/chronic fatigue syndrome, or ME/CFS.
Is the clandestine virus constantly provoking the immune system, causing symptoms? That’s one leading theory. Another possibility is that COVID triggers an autoimmune response when the body mistakenly attacks itself. Or perhaps, long after it fends off infection, the immune system fails to turn off.
Using an ultrasensitive test of blood from 171 people who had been infected with COVID, the UCSF scientists found pieces of the viral “spike” protein that persisted up to 14 months after infection.
They discovered that the likelihood of detecting the protein was about twice as high in people who had been severely ill, requiring hospitalization, than those who were not. Detection was also higher in the blood of people who reported being very sick but were not hospitalized.
In tissue samples, traces of the virus were found up to two years after infection. It was hidden in connective tissue where immune cells are located.
The work was conducted at UCSF’s Long COVID Tissue Bank, the world’s first tissue bank with samples donated by patients with long COVID.
It provides some of the strongest evidence so far that COVID antigens can persist in some people, according to Peluso.
“The UCSF team includes people who helped make HIV and AIDS a treatable disease,” according to Amy Proal, president of PolyBio, a research foundation focused on long COVID. “These researchers rapidly pivoted into long COVID research at the outset of the pandemic, leveraging years of experience performing similar research with patients with HIV and AIDS.”
Persistent COVID infections — caused by actively replicating virus — were recently reported in another study based on a large community surveillance project in the United Kingdom. It found that 1% to 3% of people had persistent infections for more than 30 days and 0.1% to 0.5% had them for more than 60 days.
This is worrisome because these persistent active infections may act as viral “reservoirs” that lead to new and highly genetically divergent lineages, seeding a future outbreak.
That study found that the risk of long COVID was 55% higher in people with persistent infection.
“We’re making considerable headway on understanding what drives long COVID,” wrote Dr. Eric Topol, director of the Scripps Research Translational Institute in La Jolla.
“Clearly finding effective and safe treatments is an urgent matter and not enough is being done to pursue that yet, despite a long list of potential alluring interventions based on mechanistic insights,” he said. “Hopefully that will get going now — it cannot happen soon enough.”
Lisa M. Krieger
seattletimes.com
My comments:
It's sad that some folks here think COVID-19 is just a "walk in the part" flu strain.
Of course we didn't. This is much more dangerous and debilitating.
E |
|
