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Biotech / Medical : Ligand (LGND) Breakout!
LGND 203.18-1.4%Nov 28 9:30 AM EST
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To: Flagrante Delictu who wrote (15308)2/19/1998 10:22:00 AM
From: Henry Niman   of 32384
 
Histone Deacetylase was also implicated in retinoblastomas a couple of weeks ago in Nature:

Retinoblastoma protein recruits histone deacetylase to repress
transcription
The retinoblastoma protein (Rb) silences specific genes that are active in the
S phase of the cell cycle and which are regulated by E2F transcription
factors. Rb binds to the activation domain of E2F and then actively
represses the promoter by a mechanism that is poorly understood. Here we
show that Rb associates with a histone deacetylase, HDAC1, through the
Rb 'pocket' domain. Association with the deacetylase is reduced by naturally
occurring mutations in the pocket and by binding of the human papilloma
virus oncoprotein E7. We find that Rb can recruit histone deacetylase to
E2F and that Rb cooperates with HDAC1 to repress the E2F-regulated
promoter of the gene encoding the cell-cycle protein cyclin E. Inhibition of
histone deacetylase activity by trichostatin A (TSA) inhibits Rb-mediated
repression of a chromosomally integrated E2F-regulated promoter. Our
results indicate that histone deacetylases are important for regulating the cell
cycle and that active transcriptional repression by Rb may involve the
modification of chromatin structure.
A Brehm, E A Miska, D J McCance, J L Reid, A J Bannister & T
Kouzarides
Retinoblastoma protein recruits histone deacetylase to repress
transcription (Letter to Nature)
Nature 391, 597 (1998)
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