Here's another HDAC1 paper on Rb:
Retinoblastoma protein represses transcription by recruiting a
histonedeacetylase
The retinoblastoma tumour-suppressor protein Rb inhibits cell proliferation
by repressing a subset of genes that are controlled by the E2F family of
transcription factors and which are involved in progression from the G1 to
the S phase of the cell cycle. Rb, which is recruited to target promoters by
E2F1 (ref. ), represses transcription by masking the E2F1 transactivation
domain and by inhibiting surrounding enhancer elements, an active repression
that could be crucial for the proper control of progression through the cell
cycle. Some transcriptional regulators act by acetylating or deacetylating the
tails protruding from the core histones, thereby modulating the local structure
of chromatin: for example, some transcriptional repressors function through
the recruitment of histone deacetylases. We show here that the histone
deacetylase HDAC1 physically interacts and cooperates with Rb. In
HDAC1, the sequence involved is an LXCXE motif, similar to that used by
viral transforming proteins to contact Rb. Our results strongly suggest that
the Rb/HDAC1 complex is a key element in the control of cell proliferation
and differentiation and that it is a likely target for transforming viruses.
L Magnaghi-Jaulin, R Groisman, I Naguibneva, P Robin, S Lorain, J P
Le Villain, F Troalen, D Trouche & A Harel-Bellan
Retinoblastoma protein represses transcription by recruiting a
histone deacetylase (Letter to Nature)
Nature 391, 601 (1998) |
