Ligand (LGND) Breakout! Message Board

STOCKTALK

We've detected that you're using an ad content blocking browser plug-in or feature. Ads provide a critical source of revenue to the continued operation of Silicon Investor. We ask that you disable ad blocking while on Silicon Investor in the best interests of our community. If you are not using an ad blocker but are still receiving this message, make sure your browser's tracking protection is set to the 'standard' level.

Biotech / Medical : Ligand (LGND) Breakout!

LGND 201.29

+0.2%

3:59 PM EST

Public Reply Prvt Reply Mark as Last Read File

Previous 10 Next 10 Previous Next

To: Flagrante Delictu who wrote (15308)	2/19/1998 10:29:00 AM
From: Henry Niman	Read Replies (1) of 32384

Here's Nature's News & Views version of HDAC1 and Rb: TRANSCRIPTIONAL REPRESSION Mutations in the retinoblastoma (Rb) tumour-suppressor protein are implicated in many types of cancer. In healthy cells, Rb binds to the E2F protein, preventing the transcription of genes that would otherwise be activated by E2F. But in cancer cells, this repression is turned off, allowing the cells to enter the cell cycle. In an attempt to find out how Rb normally effects this repression, two groups have found that it binds to the histone deacetylase HDAC1, acting as a bridge to tether this protein to E2F. The HDAC1 protein therefore represses the E2F- regulated promoter, in an interaction that is mediated by Rb. Ronald A. DePinho The cancer-chromatin connection Nature 391, 533-536 (1998)

Report TOU Violation

Share This Post

Public Reply Prvt Reply Mark as Last Read File

Previous 10 Next 10 Previous Next