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Biotech / Medical : Ligand (LGND) Breakout!
LGND 203.18-1.4%Nov 28 9:30 AM EST
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To: Flagrante Delictu who wrote (15308)2/19/1998 11:14:00 AM
From: Henry Niman   of 32384
 
Here's the Ron Evan's paper identifying SMART:

Nature 1995 Oct 5;377(6548):454-457

A transcriptional co-repressor that interacts with nuclear
hormone receptors.

Chen JD, Evans RM

Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, California 92037,
USA.

Transcriptional silencing mediated by nuclear receptors is important in development, differentiation
and oncogenesis. The mechanism underlying this effect is unknown but is one key to understanding
the molecular basis of hormone action. Here we identify a receptor-interacting factor, SMRT, as a
silencing mediator (co-repressor) for retinoid and thyroid-hormone receptors. SMRT is a previously
undiscovered protein whose association with receptors both in solution and bound to
DNA-response elements is destabilized by ligand. The interaction with mutant receptors correlates
with their transcriptional silencing activities. In vivo, SMRT functions as a potent co-repressor, and a
GAL4 DNA-binding domain fusion of SMRT behaves as a frank repressor of a GAL4-dependent
reporter. Together, our results identify a new class of cofactors which may be important mediators
of hormone action.

Comments:

Comment in: Nature 1995 Oct 5;377(6548):387-8
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