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Biotech / Medical : MGI Pharma MOGN New patents, anti cancer
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To: Biomaven who wrote (728)2/22/1998 8:18:00 PM
From: Vector1  Read Replies (3) of 1826
 
<<Could you point us to some actual examples? Were the failures because of toxicity or lack of efficacy or both>>
The examples are too numerous to list. Among the primary reasons are toxicity and the fact that Xenografted human tumors are not metastatic. There was an excellent article on this issue in the november 7th issue of Science entitled Cancer Models: Systems for identifying new drugs are often faulty. You can get a copy or at least an abstract by registering with Science on line www.sciencemag.org.
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