Here's one of the associated patents:
United States Patent
5,030,565
Niman, et. al.
Jul. 9, 1991
Polypeptide-induced monoclonal receptors to protein ligands
Inventors:
Niman; Henry L. (Carlsbad, CA); Lerner; Richard A. (La Jolla, CA).
Assignee:
Scripps Clinic and Research Foundation (La Jolla, CA).
Appl. No.:
701,954
Filed:
Feb. 15, 1985
Related U.S. Application Data
Continuation-in-part of Ser No. 1,304, Aug. 17, 1984, which is a continuation-in-part of
Ser. No. 524,084, Aug. 17, 1983, abandoned.
Intl. Cl. :
G01N 33/577
Current U.S. Cl.:
530/387.7; 422/61; 435/172.2; 435/240.27;
435/70.21; 436/548; 436/813; 530/324;
530/325; 530/326; 530/327; 530/328; 530/329;
530/387.9; 530/388.85; 530/413
Field of Search:
435/68, 172.2, 240, 70.21, 240.27; 436/548,
813; 530/387, 324-329, 413; 422/61
References Cited | [Referenced By]
U.S. Patent Documents
4,532,220
Jul., 1985
Lavi
436/813 X
4,535,058
Aug., 1985
Weinberg
436/813 X
4,699,877
Oct., 1987
Cline
435/6
Foreign Patent Documents
8403087
Aug., 1984
WO
103/52
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Primary Examiner: Nucker; Christine
Attorney, Agent or Firm: Lyon & Lyon
Abstract
Monoclonal receptors raised to immunogenic polypeptides whose amino acid residue sequences
correspond to sequences of oncoprotein ligands are disclosed, as are method for the production of
those receptors and products and methods that utilize them. The monoclonal receptors bind both to
the oncoprotein ligand to a portion of which the polypeptide corresponds in sequence, and to the
immunogenic polypeptide to which the receptors were raised.
31 Claims, 16 Drawing Figures |
