Here's the Del-1 abstract.....
Genes Dev 1998 Jan 1;12(1):21-33
Cloning and characterization of developmental endothelial locus-1: an
embryonic endothelial cell protein that binds the alphavbeta3 integrin
receptor.
Hidai C, Zupancic T, Penta K, Mikhail A, Kawana M, Quertermous EE, Aoka
Y, Fukagawa M, Matsui Y, Platika
D, Auerbach R, Hogan BLM, Snodgrass R, Quertermous T
Tokyo Women's Medical College, Tokyo 162, Japan.
We have taken advantage of an enhancer trap event in a line of
transgenic mice to identify a unique developmentally regulated
endothelial cell locus (Del1). The protein encoded in this locus
contains three EGF-like repeats homologous to those in Notch
and related proteins, including an EGF-like repeat that contains an RGD
motif, and two discoidin I-like domains. Del1 is shown
to be a matrix protein and to promote adhesion of endothelial cells
through interaction with the alphavbeta3 integrin receptor.
Embryonic endothelial-like yolk sac cells expressing recombinant Del1
protein, or grown on an extracellular matrix containing
Del1 protein, are inhibited from forming vascular-like structures.
Expression of Del1 protein in the chick chorioallantoic
membrane leads to loss of vascular integrity and promotes vessel
remodeling. Del1 is thus a new ligand for the alphavbeta3
integrin receptor and may function to regulate vascular morphogenesis or
remodeling in embryonic development. |
