Alan,
An increasing number of researchers, now believe that amyloid, beta and tau are a part of the brain’s immune system. Suppressing them is more likely to allow the pathogens that do cause Alzheimer’s to more easily attack the brain then it is to produce any benefit.
Leading edge, researchers have discovered several pathogens which contribute to Alzheimer’s disease. I believe that most people here are aware of the 2008 Report in clinical trials.gov and In pubmed Has conclusively shown that people with herpes who were aggressively treated with an antiviral are up to 80% less likely to get Alzheimer’s than those who received no treatment for herpes. The virus that causes chickenpox also leads to shingles after 40 years and if you’re not aggressively treated will lead to Alzheimer’s after another 20 to 30 years. People who get Gingivitis are also prone to get Alzheimer’s. There are also some fungi and parasites which may contribute to Alzheimer’s This research is in very early stages and more evidence is needed before that can be made as an absolute statement. Research is underway to see whether getting rid of those pathogens will also act as a treatment for Alzheimer’s But the last time I checked, it was too early to get any definitive answer.
There are about 98 phase 2 and phase 3 clinical trials to get rid of amyloid, beta and or tau which have failed Outright after completion Or failed due to futility during a scheduled checkpoint. On the other hand, The Biogen Drug aduHelm, Which had two phase 3 clinical trials, one of which failed miserably and the other showed no benefit And has been withdrawn from the market as no insurance company would cover the costs And very few doctors had any interest In it and three members of the advisory committee resigned in protest.
The FDA is desperate to find something that they can approve in the Alzheimer’s area And have actually approved a couple more drugs, which tested very, very early stage Alzheimer’s. i’d be quite surprised if either of them is able to reduce the incidents of Alzheimer’s or provide any treatment for existing disease that isn’t early stage
if you use any of the AI tools, you can get excellent answers to whatever level of detail you desire. The two that I use and that I find most helpful are ChatGPT and Gemini if you use something else, I’m sure they will give you accurate information as well.
Best regards,
Ian |
