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Biotech / Medical : Spectral Medical Inc.

EDTXF 1.100

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Oct 28 10:15 AM EDT

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From: Sultan	9/9/2025 4:35:16 PM
	of 520

A new publication in Critical Care Explorations highlights the critical relationship between endotoxin activity, organ failure, and mortality in septic shock. - Prevalence of ESS Endotoxic septic shock (ESS), defined as EAA = 0.6 combined with SOFA > 11 or MODS > 9, was present in 21 patients (23.3%) of the cohort. - Mortality Rates ESS patients had a 28-day mortality rate of 57.1%, compared to 15.9% in non-ESS patients. - Association with the d Phenotype The high-risk d phenotype was found in 33.3% of ESS patients versus 5.8% of non-ESS patients (p = 0.001). Importantly, the majority (63.6%) of all d phenotype patients in the study also had ESS. - Relative Risk of Death The relative risk of death for ESS patients was 3.58 (95% CI, 1.86–6.91), meaning patients with ESS were over 3.5 times more likely to die compared with non-ESS patients. - Read the full article here buff.ly In summary: This study demonstrates that ESS identifies a high-risk subgroup of septic shock patients with markedly higher mortality and a strong association with the lethal d phenotype.

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