Ligand (LGND) Breakout! Message Board

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Biotech / Medical : Ligand (LGND) Breakout!

LGND 206.36

+1.4%

Nov 26 3:59 PM EST

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To: Henry Niman who wrote (15855)	2/25/1998 12:23:00 PM
From: David L. Hachey	Read Replies (1) of 32384

Henry; Probably so, it's easier to dispense that way and generally more easily tolerated by patients. However, the pharmacokinetics, absorption, first-pass clearance and localized GI side effects may dictate how it's to be given. Have you seen any papers on the pharmacokinetics, etc.? Generally lipophilic drugs like targretin are slowly metabolized. Also, at thehigher doses used in cancer, would this adversely impact glucose metabolism? ...Dave

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