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patentscope.wipo.int
Section 0082 in the description mentions the increased binding affinity
BINDING AFFINITY & A VIDITY
[0082] In various embodiments, the multivalent aptamer described herein, and/or compositions or formulations comprising these multivalent aptamers, exhibit enhanced affinity and/or avidity for a target molecule. According to certain embodiments, the multivalent aptamers described herein exhibit a synergistic binding affinity and/or avidity to a target. In particular, it was unexpectedly found that the multivalent aptamers described herein exhibit an enhanced or synergistic affinity/avidity for a target molecule of up to 537.5-fold over its corresponding monomeric form. The unexpectedly enhanced affinity/avidity of the tetrameric aptamer was observed in its binding with target molecules of various forms, including monomeric, dimeric, and trimeric protein targets. Moreover, the G-quadruplex construct displayed synergistic cooperativity between each branch in binding the target molecule. |
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