Alzheimer’s Fully Reversed in Mice, Scientists Say
"The key takeaway is a message of hope."
By Sharon Adarlo
Published Dec 29, 2025
The team injected P7C3-A20 into both mice cohorts at two months of age, later finding out that this treatment successfully prevented them from developing the disease. But the big news was when they injected the compound into another batch of lab mice, who were suffering from a relatively advanced stage of Alzheimer’s at six months of age; after getting injections, these mice completely recovered their cognitive ability and NAD+ levels were restored to homeostasis leve;s
“We were very excited and encouraged by our results,” said Pieper in the statement. “Restoring the brain’s energy balance achieved pathological and functional recovery in both lines of mice with advanced Alzheimer’s. Seeing this effect in two very different animal models, each driven by different genetic causes, strengthens the new idea that recovery from advanced disease might be possible in people with AD when the brain’s NAD+ balance is restored.”
What’s also good about this study is that P7C3-A20 offers an alternative pathway to boosting NAD+ levels versus taking over-the-counter chemical precursors for NAD+, which can can raise NAD+ to such toxic levels that people could develop cancer, Pieper said. Supplements to boost NAD+ are just a click away on your cellphone, which should be worrying for anybody concerned about cancer.
The team wants to move to human clinical trials but some people are clearly not waiting; if you search online on how to obtain P7C3-A20 for yourself, numerous websites selling vials of the compound will pop up.
Alzheimer's Fully Reversed in Mice, Scientists Say |
