Stan, The two classes of transcription factors (leucine zippers and zinc fingers) are involved in controlling many genes. I'm not sure about the entire list of cancers, but recent papers have shown defects in acute promyelocytic leukemia, non-Hodgkins lymphoma, acute myelogenous leukemia, and retinoblastomas. These are some of the favorite targets for researchers, so I suspect that as more look at more types of cancers, the list will grow.
The various IRs that Ligand targets (more than 75) are all members of the zinc finger class which includes retinoic acid receptors, retinoic acid X receptors, thyroid hormone receptors, vitamin D receptors, estrogen receptors, androgen receptors, mineralocorticoid receptors, gluccocorticoid receptors, HNF4 receptors, and many of the orphan receptors such as LXR (the above list is by no means complete). |
