The Nature abstracts are now on-line. Here's one on rb and histone deacetylase:
Nature 1998 Feb 5;391(6667):601-605
Retinoblastoma protein represses transcription by
recruiting a histone deacetylase.
Magnaghi-Jaulin L, Groisman R, Naguibneva I, Robin P, Lorain S, Le Villain JP, Troalen
F, Trouche D, Harel-Bellan A
Laboratoire Oncogenese, Differenciation et Transduction du Signal, CNRS UPR 9079, Villejuif,
France.
[Medline record in process]
The retinoblastoma tumour-suppressor protein Rb inhibits cell proliferation by repressing a subset of
genes that are controlled by the E2F family of transcription factors and which are involved in
progression from the G1 to the S phase of the cell cycle. Rb, which is recruited to target promoters
by E2F1, represses transcription by masking the E2F1 transactivation domain and by inhibiting
surrounding enhancer elements, an active repression that could be crucial for the proper control of
progression through the cell cycle. Some transcriptional regulators act by acetylating or deacetylating
the tails protruding from the core histones, thereby modulating the local structure of chromatin: for
example, some transcriptional repressors function through the recruitment of histone deacetylases.
We show here that the histone deacetylase HDAC1 physically interacts and cooperates with Rb. In
HDAC1, the sequence involved is an LXCXE motif, similar to that used by viral transforming
proteins to contact Rb. Our results strongly suggest that the Rb/HDAC1 complex is a key element in
the control of cell proliferation and differentiation and that it is a likely target for transforming viruses.
PMID: 9468140, UI: 98127658 |
