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Biotech / Medical : Ligand (LGND) Breakout!
LGND 203.18-1.4%Nov 28 9:30 AM EST
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To: squetch who wrote (15999)2/27/1998 8:40:00 PM
From: Henry Niman  Read Replies (1) of 32384
 
Here's an abstract on a review of histones controlling cell division and differentiation through transcription factors:

Cell Biol Int 1996 Jan;20(1):41-49

Transcriptional control of cell cycle progression: the
histone gene is a paradigm for the G1/S phase and
proliferation/differentiation transitions.

Stein GS, Stein JL, Van Wijnen AJ, Lian JB

Department of Cell Biology, University of Massachusetts Cancer Center, Worcester 01655, USA.

The histone gene is a paradigm for transcriptional control at the G1/S phase transition point in the
cell cycle. The histone gene promoter provides a blueprint for integration of regulatory signals which
mediate responsiveness to factors controlling competency for cell cycle progression at the initiation
of DNA replication. The downregulation of proliferation at the onset of differentiation is
accompanied by and functionally linked to modifications in protein-DNA and protein-protein
interactions at histone gene promoter regulatory elements. Chromatin structure, nucleosome
organization and gene-nuclear matrix interactions facilitate crosstalk between regulatory sequences
and targeting of transcription factors to cognate binding domains.

Publication Types:

Review
Review, tutorial

PMID: 8936406, UI: 9709049
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