Harry, Bill, and all:
Some analysis/commentary added to program guide for this week's AADR meetings.
My comments are in "<<<" and ">>>"
=====================
Seq#: 89 Friday, 9:00 am - 11:00 am
Oral Session, Room 103 B
Cariology Research - Dentifrice, Fluoride
Chairpersons: B. Schemehorn and D. White
0653 9:00 A Mechanistic Model for 'Active' Fluoride Delivery Systems. L.C. CHOW*, S. TAKAGI, and M. MARKOVIC (ADAHF Paffenbarger Research Center, NIST, Gaithersburg, MD, USA).
<<< Interesting to note that ADAHF is involved in this study. Wonder if it has any relevance to remineralization toothpaste?>>>
0654 9:15 De/Remineralization of Artificial Enamel Lesion with a pH Cycling Model. A. OMRAN* and J.S. WEFEL (Dows Institute for Dental Research, University of Iowa, Iowa City, USA).
0655 9:30 Effect of Tartar Control Anions on Enzymatic SMFP Hydrolysis. K.N. DAHL, D.J. WHITE, and E.R. COX* (The Procter & Gamble Co., Cincinnati, OH, USA).
0656 9:45 F Clearance/SMFP Hydrolysis from Tartar Control Whitening Toothpastes. K.N. DAHL, D.J. WHITE*, and E.R. COX (The Procter & Gamble Co., Cincinnati, OH, USA).
<<< Two studies sponsored by P&G. >>>
0657 10:00 Bio-availability of Fluoride in Remineralizing Toothpaste Containing Calcium Salt. B.R. SCHEMEHORN*, G.D. WOOD, and A.E. WINSTON (Indiana University School of Dentistry, Indianapolis; and Enamelon, Inc., East Brunswick, NJ, USA).
<<< Now we're talking about the effectiveness of fluoride here, not enhanced remineralization. So this study might talk about why Dr. Stookey said Enamelon works 10-15% better as a fluoride toothpaste. BTW, Dr. Stookey is affiliated with Indiana University School of Dentistry. This sounds like a key study - one that really upset a few folks, resulting in smear campaign through Bearron's!
So this is study #1 of 5, but does not deal with enhanced remineralization.>>>
0658 10:15 Intra-oral Remineralization of Enamel with a Novel Dentifrice. T. YASKELL*, S. KASHKET, and A.E. WINSTON (Forsyth Dental Center, Boston, MA; and Enamelon, Inc., East Brunswick, NJ, USA).
<<< Sounds like we're talking about enhanced remineralization here. So this is study #1 for enhanced remineralization. >>>
0659 10:30 Effects on Remineralization and Acid Resistance from Conventional and "Remineralizing" Toothpastes. R.V. FALLER* and A.M. PFARRER (The Procter & Gamble Company, Cincinnati, OH, USA).
<<< Lookie here! We have a P&G sponsored study on remineralization. And look, there's no affiliation with a dental school listed. Perhaps P&G wanted to do their own testing so that it could defend against Enamelon's advertising claims (Er, I mean, through published peer-review material, whill all along following FDA guidelines). >>>
0660 10:45 Comparison of Decision Rules for Approving Anticaries Drug Products. H. LI*, M.E. MOSS, and D.T. ZERO (University of Rochester Eastman Dental Center, NY, USA
<<< This is off topic, but seems to be relevant, in our discussion of FDA approval. >>>
Seq#: 142 Friday, 4:00 pm - 5:00 pm
Poster Session, Exhibit Hall 1
Dental Materials - Biocompatibility/Fluoride Release
1080 Estrogenic Activity of Combined Administration of Two Possible Dental Resins. B.A. CHERRY*, P.C. MOON, and M.Y. KALIMI (Medical College of Virginia, Virginia Commonwealth University, Richmond, USA).
1081 In vitro Elution of Leachable Components from Dental Sealants. D. NATHANSON, P. LERTPITAYAKUN*, M.S. LAMKIN, M. EDALATPOUR, and L. CHOU (Goldman School of Dental Medicine, Boston University, MA, USA).
1082 Estrogenicity of Bisphenol-A and Bisphenol-A Dimethacrylate in Dental Resins. T. SCHAFER* and C.A. LAPP (Medical College of Georgia, Augusta, USA).
1083 Cytotoxicity of Casting Alloys Pre-treated with Saline or Medium. S.K. NELSON*, J.C. WATAHA, R.M. CIBIRKA, and P.E. LOCKWOOD (Medical College of Georgia, Augusta; and University of Detroit, MI, USA).
1084 Cytotoxicity of Lipopolysaccharide on Chrome- cobalt, Titanium, and Titanium Alloy. R.M. CIBIRKA*, J.C. WATAHA, S.K. NELSON, and P.E. LOCKWOOD (Medical College of Georgia, Augusta, USA).
1085 Effect of pH on Elemental Release from Dental Casting Alloys. P.E. LOCKWOOD*, S.S. KHAJOTIA, and J.C. WATAHA (Medical College of Georgia, Augusta; and College of Dentistry, University of Oklahoma, Oklahoma City, USA).
1086 Initial vs. Long-term Elemental Release from Dental Casting Alloys. J.C. WATAHA*, P.E. LOCKWOOD, and S.K. NELSON (Medical College of Georgia, Augusta, USA).
1087 Inhibition of Human Gingival Fibroblast Proliferation by Sodium Perborate. E. NELSON*, S. EVANS, and C. LEONE (Tufts University, Boston, MA, USA).
1088 Release and Uptake of Fluoride from Fluoride-containing Dental Materials. R.P. CHRISTENSEN*, B.J. PLOEGER, R.A. HOLLIS, and T.P. CROLL (Clinical Research Associates, Provo, UT; and Private Practice, Doylestown, PA, USA).
1089 In vitro Fluoride Release and Antimicrobial Activity of Restorative Compomers. G.D.P.C. AGUILAR*, O.P.S ROSA, E.M. TAGA, and B. COSTA (Faculty of Dentistry of Bauru, USP, Sao Paulo, Brazil).
1090 Fluoride Release for Experimental and Commercial Materials. A.S. RIZKALLA*, D.W. JONES, and M. LANGMAN (Division of Biomaterials, Dalhousie University, Halifax, Nova Scotia, Canada).
1091 Fluoride Release and Compressive Strength of Fluoride-releasing Materials. X. XU* and J.O. BURGESS (LSUMC-School of Dentistry, New Orleans, LA, USA).
1092 Caries Model for Comparing Anti-cariogenic Properties of Restorative Materials. E.J. DeSCHEPPER* and B.W. BENEDICT (School of Dentistry, Indiana University, Indianapolis, USA).
1093 Strengthening of Tooth Enamel by Remineralizing Toothpaste. C.A. MUNOZ*, R. FELLER, A. HAGLUND, A.E. WINSTON, and C.W. TRIOL (School of Dentistry, Loma Linda University, CA; and Enamelon, Inc., NJ, USA).
<<< Here is another, yet critical, study supporting advertising claims that Enamelon strengthens tooth enamel. Call it #2 which supports "enhanced" remineralization claims. >>>
1094 Evaluation of Molding and Handling Properties of Hydroxyapatite Paste. Y. FUKASE*, S. WADA, H. UEHARA, N. USUI, H. SATO, and M. NISHIYAMA (School of Dentistry, Nihon University, Tokyo, Japan
Seq#: 145 Friday, 4:00 pm - 5:00 pm
Poster Session, Exhibit Hall 1
Cariology Research - Dentifrices, Fluoride Uptake, Root Caries
1124 Remineralization Potential of Conventional and Novel Toothpastes: Rat Model Testing. J.M. BEST*, S.L. EVERSOLE, and R.V. FALLER (The Procter & Gamble Company, Cincinnati, OH, USA).
<<< Second P&G study on remineralization potentials. Again no listing of corroborating dental schools. However, would be interesting to note if these results align with other pilot findings, now wouldn't it? >>>
1125 In vitro pH Cycling Assessment of a New Multi-functional Toothpaste. S.L. EVERSOLE*, E.R. BITTEN, R.V. FALLER, and J.D.B. FEATHERSTONE (The Procter & Gamble Company, Cincinnati, OH; and UCSF, San Francisco, CA, USA).
<<< Now P&G lists UCSF here. Wasn't there a dentist who taught at UCSF, I think Bill Wexler wrote:
"I had a long conversation with my dentist regarding Enamelon. (BTW - he currently teaches at UCSF).
Bottom line - he was extremely skeptical. He felt that the remineralization claims amounted to voodoo chemistry and completely worthless without good clinical data from human tests. "
So is this dentist sponsored to do P&G research - for the multi-functional new toothpaste? Bill, please check this out for us. Your source might be a source of a conflict of interest. >>>
1126 The in vitro Demineralization Prevention Potential of a NaF/Calcium-phosphate-containing Dentifrice under Various Experimental Conditions. S. KARDOS*, B. SHI, and T. SIPOS (Digestive Care, Inc., Bethlehem, PA, USA).
1127 A Pilot Human Clinical Study Evaluating ENAMELON Fluoridated Dentifrice in the Remineralization of Early Dental Caries. L.E. WOLINSKY*, P. CHAMKASEM, S. JASON, C.W. TRIOL, and A.E. WINSTON (UCLA School of Dentistry, Los Angeles, CA; and Enamelon, Inc., East Brunswick, NJ, USA).
<<< Sounds like another pilot supporting enhanced remineralization. That makes #3 of 5.>>>
1128 Cariostatic Effect of a Two-part Fluoride Dentifrice in Rats. S.A. MUNDORFF-SHRESTHA*, H.M. PROSKIN, G. CORNELL, and T. SHARPE (University of Rochester Eastman Dental Center, NY, USA).
<<< Is this Enamelon study #5? It does not focus on reminearlization, but on the cariostatic effects of a two-part fluoride dentifrice. Does that fit the description of Enamelon, or what? And the school is down the street from Enamelon HQ.>>>
1129 Caries Profile Testing of a New Dentifrice Containing a Modified Silica. A.M. PFARRER*, W.F. LANDRIGAN, J.M. BEST, S.L. EVERSOLE, and R.V. FALLER (The Procter & Gamble Company, Cincinnati, OH, USA).
<<< This is interesting. Don't think FDA has approved such a study either, but P&G can certainly lay claim to any legit findings, just as ENML can. Interested in this as well, as it relates to whitening aspects. >>>
1130 Correlation between Fluoride Release and in vitro Fluoride Uptake. S.W. FISHER*, B.R. SCHEMEHORN, E.A. TAVSS, R.J. GAMBOGI, and M.T. JOZIAK (Colgate-Palmolive, Piscataway, NJ; and School of Dentistry, Indiana University, Indianapolis, USA).
<<< First study co-sponsored by Colgate-Palmolive with Indiana University School of Dentistry. Dr. Stookey's group also gets paid by Colgate-Palmolive. Any guesses on who might have fed Bearron's those "facts" on Enamelon? Anybody? >>>
1131 Surface Alterations of Tooth Enamel Observed by AFM Technique. M. UEMURA* and M. KAMBARA (Department of Preventive Dentistry, Osaka Dental University, Japan).
1132 Effect of a Chlorhexidine Varnish on Dentinal Ca2+/PO3 Levels after Demineralization. K.-H. TRAN*, J. VOGEL, R.N. D'SOUZA, J. NOR, W. CHAN, and W.A. BRETZ (University of Texas, Houston; and University of Michigan, Ann Arbor, USA).
1133 Measurement of Root Dentin Demineralization Using Microradiography and Confocal Microscopy. S. HART*, C. GONZALEZ-CABEZAS, M. FONTANA, M.E. WILSON, and G.K. STOOKEY (School of Dentistry, Indiana University, Indianapolis, USA).
1134 An in vitro Microbial Model for Studying Root Caries Formation. M.S. AUSTIN*, M. FONTANA, C. GONZALEZ-CABEZAS, M.E. WILSON, and G.K. STOOKEY (School of Dentistry, Indiana University, Indianapolis, USA).
<<< Two more studies under supervision of Dr. Stookey. >>>
1135 Surface Morphology of Root Surfaces after Argon Laser and APF Treatment. G. WESTERMAN*, J. HICKS, C.M. FLAITZ, R.J. BLANKENAU, and L. POWELL (Creighton University, Omaha, NE; University of Texas; Baylor College of Medicine, Houston; and University of Utah, Salt Lake City, USA).
=========================
That makes four studies mentioning Enamelon. Where's the 5th, which does NOT foucs on enhanced remineralization? Perhaps the 5th is here, it's just that Enamelon was not mentioned.
Anxiously awaiting until there are links to these papers, including the P&G findings. Friday is going to be one interesting day!
Greg |
