Here's the initial abstract on neu:
Nature 1984 Dec 6;312(5994):513-516
The neu oncogene: an erb-B-related gene encoding a
185,000-Mr tumour antigen.
Schechter AL, Stern DF, Vaidyanathan L, Decker SJ, Drebin JA, Greene MI, Weinberg
RA
A series of rat neuro/glioblastomas all contain the same transforming gene (neu) which induces
synthesis of a tumour antigen of relative molecular mass (Mr) 185,000 (p185). The neu oncogene
bears homology to erb-B and the tumour antigen, p185, is serologically related to the epidermal
growth factor (EGF) receptor. The two proteins, EGF receptor and p185 appear to be distinct, as
they coexist in nontransformed Rat-1 cells.
PMID: 6095109, UI: 85061595 |
