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Biotech / Medical : MGI Pharma MOGN New patents, anti cancer
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To: David Cathcart who wrote (764)3/5/1998 5:01:00 PM
From: gy  Read Replies (1) of 1826
 
Following data will present in 9th Annual Meeting, American Association for Cancer Research March 28-April 1, 1998 New Orleans, LA

#1553 MGI114, currently in phase I human trial, and scheduled for phase II human trial against a variety of solid tumors, was found to markedly inhibit tumor growth(p<0.001) in HL60/MRI myeloid leukemia xenograft model, at 7mg/kg(dailyx5,i.p.)and 10mg/kg(3x/week i.p.)for 3 weeks, with tumor growth inhibition significantly greater than that of other illudin analogs and several conventional antitumor agents. The result suggested MGI114 against myeloid leukemia should be evaluated in phase II clinic trials.

#3585 Evidence of synergistic antitumor with MGI114 in combination with irinotecan(ITN) or 5-Fluorouracil(5-FU) against a human colon tumor xenograft model.

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