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Biotech / Medical : Biomatrix (BXM) Looking Great

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To: McMark who wrote (425)	3/6/1998 1:09:00 AM
From: John McCarthy	of 569

McMark - Please note the following with respect to your question. (1) The success rate of Synvisc with respect to STAGE 1 / 2 / 3 OA is about 70%. This per a Canadian Restrospective study done in 1996. This success rate has nothing to do with what you are talking about. (2) Again - to my knowledge - Synvisc DOES NOT WORK ON BONE ON BONE. PERIOD. (3) Synvisc works very well on Patellofemoral Chondromalacia but nobody is aware of this. And Synvisc is NOT labelled for this. (4) The doctor below - to my knowledge - knows more about Synvisc - in terms of usage/patients than anyone else in the world. Contact him. (I don't know him - he is Canadian) Below his name is a post he wrote in Sept 97. I have edited it for brevity. ============================================================ Dr. R. Timothy Deakon Sports Injury Clinic 250 Wyecroft Rd., Unit 18 Oakville, Ontario, CANADA L6K 3T7 Ph 905 849 7220 Fax 905 849 7238 e-mail: kneedoc@wchat.on.ca ============================================================ He posted in Sept 1997 ... (edited by John McCarthy) ============================================================ Viscosupplementation for osteoarthritis of the knee When people ask about "gel" injections in the knee for osteoarthritis I assume they are asking about the use of hylauronic acid derivatives that are just now becoming available for use in the US. Hylan GF-20 has been available as an intraarticular injectable since 1993 in Canada. Synvisc has been available in Sweden since 1995. *************************************** I have used both Synvisc and Suplasyn for the past 3 years, completing about !!!!!!! 350 courses of the injections !!!!!!! *************************************** Synvisc consists of three prepackaged syringes containing 2cc each of Hylan GF-20. These are injected weekly for three weeks. The hyaluronic acid derivative is extracted from rooster combs and is polymerized and crosslinked. Allergy to eggs or chicken is a contraindication to treatment. Synvisc works best in early osteoarthritis or in knees that fail to improve after arthroscopy. It also seems to work in some cases of more advanced OA. It is unlikely to work where a significant malalignment exists or where the OA is full compartment bone on bone. I have had some good results in severe patellofemoral chondromalacia although the company does not promote this use. The injections MUST be intraarticular. Intrasynovial or extraarticular injections will not work and are much more likely to produce inflammatory reactions. These reactions still occur with intraarticular injections in an incidence of about 1-2 %. I have changed my injection technique to ensure it gets in the joint. The response rate in good candidates appears to be about 65-70%. Some responses are more dramatic than cortisone and their effect can last 6-18 months. I have one patient who has had 5 courses of the stuff and he swears by it (he is a physician by the way). The basic science work shows this agent only stays around in the joint for 3-4 days so who knows how it works, but the patients are certainly happy. The key is to use it on knees that are not yet too bad. American physicians should make themselves aware of these agents as many patients come into the office requesting this treatment. If you act with disbelief or resistance the patient will go elsewhere. Deak ============================================================ End of his post ============================================================ Regards, John McCarthy

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