Here's a more recent review:
Science 1997 Sep 12;277(5332):1630-1635
STATs and gene regulation.
Darnell JE Jr
Laboratory of Molecular Cell Biology, Rockefeller University, New York, NY 10021, USA.
STATs (signal transducers and activators of transcription) are a family of latent cytoplasmic proteins that are activated to
participate in gene control when cells encounter various extracellular polypeptides. Biochemical and molecular genetic
explorations have defined a single tyrosine phosphorylation site and, in a dimeric partner molecule, an Src homology 2 (SH2)
phosphotyrosine-binding domain, a DNA interaction domain, and a number of protein-protein interaction domains (with
receptors, other transcription factors, the transcription machinery, and perhaps a tyrosine phosphatase). Mouse genetics
experiments have defined crucial roles for each known mammalian STAT. The discovery of a STAT in Drosophila, and most
recently in Dictyostelium discoideum, implies an ancient evolutionary origin for this dual-function set of proteins.
Publication Types:
Review
Review, tutorial
PMID: 9287210, UI: 97433375 |
