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Biotech / Medical : Ligand (LGND) Breakout!

LGND 196.57

+4.0%

Jan 14 3:59 PM EST

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To: Hippieslayer who wrote (16762)	3/7/1998 11:45:00 PM
From: Pseudo Biologist	Read Replies (2) of 32384

Fugazi, let me try. For certain disease conditions activation of the G-CSF receptor is a good thing. How good? Well Amgen makes sells a drug called Neupogen to do just that and it generates hundreds of millions (if not close to a billion) in sales per year. This is used, roughly, to help rebuild a patient's white blood cell population after rounds of chemotherapy and/or radiation. Indirectly, use of this drug helps fight cancer. Now, Neupogen is a protein , meaning it has to be injected, and is expensive to manufacture. A pill version of this would be a big seller (assuming Geron does not cure ALL cancers first, -g-). The Lake Tahoe/Keystone results hints - I do mean hints - that it may be possible to come up with small molecules (which may be made into pill formulations) that act like Neupogen (or Leukine if the receptor turns out to be GM-CSF as first reported. On this point I know what has been posted here). How long from this interesting result to a clinical trial, let alone a drug?? Hard to tell. It may be a few years. PB

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