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Biotech / Medical : IDPH--Positive preliminary results for pivotal trial of ID
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To: scaram(o)uche who wrote (1516)3/14/1998 5:31:00 AM
From: Maurice Winn  Read Replies (1) of 1762
 
Thanks for the comments Rick. While the tumor might recur wearing different clothing, it presumably take a bit of time to go through the necessary cell divisions and mutations. Just how long does it take a malignant B-cell to go through its reproductive cycle? I guess a few days judging from how fast a tumor can grow. In fact it must depend on the individual cell type somehow since the low grade ones seem to take ages - with patients lasting a decade.

When they take blood to prepare the vaccine for the individual patient, they must be able to target the clothing which is present at that time. I thought that vaccine would act in a few days before the B-cells would have much chance to do much in the way of mutations into wolf2 clothing. But I guess there are a lot of them and one escapee malignant cell is all it takes.

While the Russian 5 year plan "Everyone Shall Wear Size 8 Shoes" is efficient for production, individually tailored treatment seems obvious when DNA and those little bits of protein and individual mutation seem so personal. The argument against it has been cost. So give everyone cyclophosphamide. But with gene chip arrays and all that jazz, individual treatment is looking sensible.

I don't know quite what "...antigen-pulsed dendritic cells..." means. In fact I have little idea at all. But it sounded good to me too. What does antigen-pulsed mean? I guess dentritic cells have dendrites. Some sort of morphology. Part of the "look through the microscope" definition of cells according to their shape I guess.

I guess a naked vaccine is one without radioactive isotopes stuck on? Yes? That's what they mean by naked monoclonal antibodies.

Then you mentioned "...an adjuvant within the same gene construct as the idiotype antigen". It is isn't that I don't know what you aren't talking about. I'm just not sure what you are. I guess it means that you find out what is the typical antigen sticking out in public, ready to get belted, then plonk something extra on the gene which is typical for the lymphoma. Which makes it easier to target the lymphoma cells.

Thanks for the comments,
Maurice
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