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Biotech / Medical : Chromatics Color Sciences International. Inc; CCSI

CCSI 28.92

+3.1%

11:07 AM EDT

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To: baggo who wrote (1366)	3/17/1998 12:07:00 AM
From: Dan Packer	Read Replies (1) of 5736

Hey Doc, I gather that you're the resident expert on this gizmo. Perhaps you could answer some questions about it. I gather this is a portable device to measure bilirubin. I gather that it would be used for routine screening for the stuff. Do you see it being used on all newborns? Would it be used on all infants newborn or not? Would it be done on admission to the hospital (or birth) only, or daily, or?? Where is the bilirubin that it measures? Is it in the serum? Is it in the whole blood? Is it in the tissue? Is it in the brain tissue? You mention oximetry. Does it measure pulsatile bilirubin like in pulse oximetry? Is there fancy circuitry like that? Or is it simple colorimetry? You say that there will be a razor and razor blade business model. What would you say is the razor blade? Is it a plastic covering? Is the blade a high profit margin item? Assuming the gizmo becomes a staple, what keeps you or me from producing a portable colorimeter to knock it off? Will this particular device have exclusivity via FDA approval? My understanding is that the issue is not total bilirubin. The issue is bound versus unbound bilirubin. Does this gizmo measure one or both of these things? Will this gizmo be a tool for screening, treating, or both? You mentioned that this gizmo could be used for anemia. Would you add one of these to your pulse oximeter to measure red cell mass? Do you see this as a screening tool for anemia? In high school biology we learned how to run a hematocrit. We drew blood up into a tiny glass capillary tube. We pushed play doh into one end of the tube and spun it for a few seconds in a little bitty centrifuge. Do you do that anymore? We learned how to measure the red part of the blood and the clear part of the blood in the tube. The % of red part to the whole column of blood, we called the hematocrit. That seemed to be a pretty cheap way to measure whether or not the sheep had anemia. We put the clear end of the tube into a colorimeter that was called a spectrophotometer and were able to measure various things dissolved in the blood. Can you do this with bilirubin? Reason I ask is that it seemed pretty cheap to do it that way. And the last time I gave blood I saw several of those centrifuge machines. How much do you think that an exam with one of those gizmos would cost? I saw you said that a blood test for bilirubin costs about $26/test. Would this gizmo eliminate the need for those tests? My uncle was in the hospital last year for alcoholism. They said his bilirubin was up. He got tests every day. Would this machine eliminate those tests? Do you think my uncle has kernicterus? Thanks, Dan

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