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Biotech / Medical : Chromatics Color Sciences International. Inc; CCSI
CCSI 20.23-4.8%Nov 20 3:59 PM EST
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To: wlheatmoon who wrote (1450)3/18/1998 5:05:00 PM
From: Dan Packer  Read Replies (2) of 5736
 
Mike thanks for your response. In fact the issue is bound v. unbound bilirubin in Kericterus. Conjugated v unconjugated might be interesting in Rotor's syndrome or somesuch. And that can be a fooler if you try to make diagnoses on the basis of color alone.

To prevent Kernicterus, you relate total bilirubin to serum protein levels. You be guessing about the partition function between bound and unbound. Since lots of drugs can compete for binding sites you would really like an independent measure of unbound bili. But that's a nasty problem, and expensive.

This device tells you that the baby is yellow, period. You apparently can quantitate the yellowness. If there is a certain amount of yellowness you draw a blood test and prove it. Then you treat. First with light. And you follow with the gizmo. Does the gizmo measure plasma yellowness or total tissue yellowness? It makes a difference. The treatment decisions are made on the amount of plasma bilirubin related to the amount of plasma protein. The issues to be solved include: is the photo therapy working? (should the kid wear Oakley's or Bolle's?) How long to continue? And the key decision is when to do an exchange transfusion. You need blood test confirmation for that. If the colorimeter will reliably answer these questions, then you have an interesting product. I suspect that you will always require blood confirmation. And I suspect that screening for total bili costs more like $1 rather than $20. So I think that the market you're going after is significantly smaller than the $300 million mentioned in the Sept '97 conference call.

Dan
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