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Biotech / Medical : SIBIA Neurosciences (SIBI)
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To: Frank Stein who wrote (163)3/19/1998 4:07:00 PM
From: Wesley Turnblot  Read Replies (1) of 579
 
Frank,

Thanks for the lively response.

I don't believe that correlational studies and specifically, that the research linking APP and presenilin mutations/ aluminum & zinc/ estrogen/ APOE are worthless. I would say though that they don't always enable us to sort clearly cause from effect (i.e. amyloid deposition and neurodegeneration, ACh and AD progression).

To be more explicit, I wouldn't invest my time or money into research towards pharmacological interventions aimed at ACh as I intuitively feel that they are downstream of more worthy candidates for positive intervention/prevention of AD.

Regards,
Wes Turnblot
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