<<Its chances of being a commercial success are worse. Adrenergic antagonists, notably alpha-two blockers, for erectile dysfunction are an old old idea, and if phentolamine were genuinely good, it would have already been done by the big boys.>>
Alex, I agree entirely. The good stuff about vasomax is outweighed by the negatives. The approval of the patent confirms that the only thing special about vasomax is the combination of phentolamine with a superdisintegrant. The one they are using is the industry standard (Ac-di-sol)(any chemists out there who can confirm this) and found in tablets as common as aspirin, so it is hardly novel! I was surprized they were granted a patent, but I'm not a patent attorney so what do I know.
Phentolamine's effectiveness is more than controversial. It has already been used in tablet form for ED. It is known to be a weak medication for ED. I doubt that the tablet dissolving in your stomach a little faster is going to change that very much.
Also the listed side-effects are marked hypotension, cardiac arrhythmias, angina, tachycardia, nausea, vomiting, abdominal pain, diarrhea, exacerbation of peptic ulcer disease.
In terms of a new drug application, does anyone know whether the FDA would formally approve oral phentolamine as a recognized treatment for ED i.e., the old generic stuff could still be used, or would vasomax be unique enough (considering its formula) to be considered a truly new drug?
Kent |
