Ligand (LGND) Breakout! Message Board

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Biotech / Medical : Ligand (LGND) Breakout!

LGND 184.82

-2.0%

Dec 5 9:30 AM EST

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To: Henry Niman who wrote (18521)	4/2/1998 2:30:00 PM
From: tuck	Read Replies (1) of 32384

Henry, Thanks for that info. I now remember the debate over the wording of that press release. Was the protocol for the European trial ever made public? At least my source has the TG info right. I must say, though, that since the doses are likely lower for diabetics in which such a spike is bad, then the spike would probably not occur in those cases. Thus if the spike is my source's only "major" concern about Ligand's retinoids, we should feel pretty good about them. Only folks with cancer and diabetes, a small population, might have a problem with it. So let's see if I've got this right. Retinoids could both elevate (per the cited press release) and lower (per the mouse data Henry posted a short while ago) TG levels. I gather it is all dose dependent and that there are two different mechanisms at work. Tuck

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