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Biotech / Medical : Ionis Pharmaceuticals (IONS)

IONS 82.81

+0.2%

3:15 PM EST

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To: SnowShredder who wrote (1900)	4/7/1998 3:21:00 AM
From: Miljenko Zuanic	Read Replies (1) of 4676

Where'd... There is not and will not be (at least in next 20 years, imo) cancer monotherapy regime which can address all aspect for successful cancer drug. Combination of two or three different drug which are complementary and synergistic (where one drug potentate others effects) in anticancer activity is for now correct approach. So, antisense (whatever is their primary target: oncogene, signal induction, grow factor, angiogenesis,...) are not designee as monotherapy. If they can (lady with ovarian cancer show that it can) increase therapy regime efficiency to be warranted and where combine side effects are tolerable, they will have place on market. When monotherapy (antisense) show promised efficiency in PII, combination therapy is next step. Very few late stage trials are still designed as monotherapy, I guess not many are in practice. mz

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