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Biotech / Medical : Ligand (LGND) Breakout!
LGND 208.29-0.3%Nov 11 3:59 PM EST

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To: Bryce Elkins who wrote (18745)4/7/1998 6:20:00 AM
From: Henry Niman  Read Replies (3) of 32384
 
Here's LGND's latest patent:
United States Patent
5,733,738
Niman
Mar. 31, 1998

Polypeptide-induced monoclonal receptors to protein ligands
Inventors:
Niman; Henry L. (Carlsbad, CA).
Assignee:
Ligand Pharmaceuticals (San Diego, CA).
Appl. No.:
418,898
Filed:
Apr. 7, 1995

Related U.S. Application Data
Continuation of (including streamline cont.) Ser. No. 925,815, Aug. 4, 1992, abandoned, which is a continuation of
Ser. No. 779,143, Oct. 21, 1991, abandoned, which is a continuation of Ser. No. 393,267, Aug. 12, 1989,
abandoned, which is a continuation-in-part of Ser. No. 232,395, Aug. 12, 1988, abandoned, which is a
continuation-in-part of Ser. No. 118,823, Nov. 9, 1987, abandoned, which is a continuation-in-part of Ser. No.
39,534, Apr. 16, 1987, Pat. No. 5,015,571, which is a continuation-in-part of Ser. No. 736,545, May 21, 1985,
abandoned, which is a continuation-in-part of Ser. No. 701,954, Feb. 15, 1985, Pat. No. 5,030,565, which is a
continuation-in-part of Ser. No. 524,804, Aug. 17, 1983, abandoned.

Intl. Cl. :
G01N 33/574
Current U.S. Cl.:
435/7.23; 436/503; 436/548; 436/813
Field of Search:
424/138.1, 155.1, 174.1; 435/7.23, 240.27; 436/503, 548,
64, 813; 530/324, 325, 326, 327, 328, 329, 387.7, 388.8,
389.7, 808, 828

References Cited | [Referenced By]

U.S. Patent Documents
4,452,901
Jun., 1984
Gordon et al.
435/7
4,532,220
Jul., 1985
Lavi
436/813 X
4,535,058
Aug., 1985
Weinberg
436/813 X
4,786,718
Nov., 1988
Weinberg et al.
436/813 X
5,030,563
Jul., 1991
Niman et al.
435/70.21
5,081,230
Jan., 1992
Carney
530/387

Foreign Patent Documents
0108564
Oct., 1983
EP
0177814
Sept., 1985
EP
0203587
May, 1986
EP
0318179
Nov., 1988
EP
8403087
Feb., 1984
WO

Other References

"Oncogenes and oncagene proteins", Brandt-Ravt et al.

Occupational Medicine: State of the Art Reviews 2(1) pp. 27-38 (1987).

"Activation of H ras Oncogene in Rat Bladder Tumors induced by N-Betyl-N-(4 Hydroxybutyl) Nitrosamine" Fujita et
al., J. Natl. Cancer Inst. 80(1): 37-43, 1988.

Brandt-Rauf, et al, "Serum Oncogene Proteins in Foundry Workers," J. Soc. Occup. Med. (1980), vol. 40, pp. 11-14.

Brandt-Rauf, et al, "Serum Oncoproteins and Growth Factors in Asbestosis and Silicosis Patients," Int. J. Cancer,
(1992) vol. 50, pp. 881-885.

Forth et al. Monoclonal Antibodies to the p 21 Products of the Transforming Gene of Harvey Murine Sarcoma Virus
and of the Cellular rasGene Family. J. Vrol. 43:294-304.

Brandt-Rauf, P., Occupational Medicine: State of the Reviews 5:59-65 (1990).

Brandt-Rauf, P. and Niman, H.L., British J. Indus. Med. 45(10): 689-693 (Oct. 1988).

Brandt-Rauf, P., J. Occup. Med. 30: 399-404 (May 1988).

Brandt-Rauf, P., et al., J. Soc. Occup. Med. 39: 141-143 (1989).

Green, et al., Cell 28: 477-487 (Mar. 1982).

Sutcliffe, et al., Science 219: 660-666 (Feb. 1983).

Wilson, et al., Cell 37: 767-778 (1984).

Bizub, et al.Oncogene 1: 131-142 (1987.

Niman, et al.PNAS-USA 82: 7924-7928 (Dec. 1985).

Primary Examiner: Saunders; David
Attorney, Agent or Firm: Lyon & Lyon LLP

Abstract

The present invention relates to immunological receptors and ligands, and more particularly to monoclonal receptors raised to
peptides whose amino acid residue sequences correspond to sequences of retroviral ligands. The receptors are used to assay
body samples from a host to indicate exposure of the host to a carcinogen.

6 Claims, 58 Drawing Figures
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