Ligand (LGND) Breakout! Message Board

STOCKTALK

We've detected that you're using an ad content blocking browser plug-in or feature. Ads provide a critical source of revenue to the continued operation of Silicon Investor. We ask that you disable ad blocking while on Silicon Investor in the best interests of our community. If you are not using an ad blocker but are still receiving this message, make sure your browser's tracking protection is set to the 'standard' level.

Biotech / Medical : Ligand (LGND) Breakout!

LGND 199.07

-3.4%

Nov 20 3:59 PM EST

Public Reply Prvt Reply Mark as Last Read File

Previous 10 Next 10 Previous Next

To: JOEBT1 who wrote (18948)	4/12/1998 12:48:00 PM
From: squetch	Read Replies (1) of 32384

I found this paper from Wyeth-Ayerst. TNF-alpha and 9-cis-RA Synergistically Induce ICAM-1 Expression: Evidence for Interaction of Retinoid Receptors w/ NF-kB >>This study provides the first demonstration fo a synergistic control of ICAM-1 protein expression by TNF-alpha and 9-cis-RA...In summary, this study demonstrates that ICAM-1 is synergistically regulated at the transcriptional level by TNF-a and 9-cis, via the functional interaction of NF-kB p65 homodimers w/ RAR/RXR heterodimers. Since enhanced ICAM-1 expression occurs in a number of diseases and pathological conditions, including atherosclerosis, arthritis, nephritis, and stroke, it is possibe that retinoid receptor/NF-kB(Nuclear factor kappa B) interaction may play a role in the progression of such disaeses.<< Experimental Cell Research 239, 423-429 Chadwick, Shaw and Winneker

Report TOU Violation

Share This Post

Public Reply Prvt Reply Mark as Last Read File

Previous 10 Next 10 Previous Next