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Biotech / Medical : American Home Products AHP

AHP 10.38

+0.3%

Apr 23 5:00 PM EST

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To: Marty Rubin who wrote (84)	4/20/1998 6:16:00 AM
From: Henry Niman	of 169

Today's WSJ has an article of designer estrogens and androgens. Ligand is not specifically mention in the WSJ article (although Ligand was mentioned in the initial WSJ article on designer estrogens, aka SERMs or TSEs home.att.net but its programs certainly are (with PFE and AHP's TSE424). The article hasn't quite progressed to combination therapy (with SERMs and Rexinoids which is the subject of one of the LLY programs with LGND), but it does mention prostate cancer and LGND's pipeline timeline (linked to home.att.net or accessed directly at home.att.net ) clearly shows that LGND's designer androgen, LGD1331, is ready to enter the clinic. CNBC just mentioned Evista and braest cancer prevention and, as ASCO approaches (conference is next month), I expect such an application to be discussed with increasing frequency in the popular press (Evista produced a 75% reduction in the incidence of breast cancer compared to the 45% seen for Tamoxifen).

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